
The complex regeneration of biochemical energy sources represents a cost-intensive hurdle for many production and research processes. Our project builds new bridges between space research and microbiology, and multiple efforts have been done to promote space synthetic biology as a truly promising and exciting scientific field. Since astronauts' tastes are altered by physiological changes in their body, we give them the choice to choose their favorite flavors by using optogenetic systems. As a proof of concept, the yeast has been engineered to produce provitamin A, an essential vitamin for human health. This system uses minimal resources which are currently considered as waste on spacecraft. We designed a quasi-autonomous coculture between the acetogen bacterium Clostridium ljungdahlii and the yeast Saccharomyces cerevisiae. iGEMINI aims to supplement astronauts’ food with nutritional and tasty yeast supplement. Some essential nutrients, such as vitamins, cannot be stored on the spacecraft since they rapidly lose nutritional value over time. Space exploration drives us further away from Earth and will lead to year-long space travel.

Finally, to prevent forthcoming infections, our third goal is to provide a prevention system based on subunit vaccines encapsulated in alginate beads. Additionally, we created a novel treatment method which relies on a quorum sensing mechanism and exolysin protein with the aim of decreasing antibiotic consumption levels. To detect the infection as soon as possible, we developed a rapid detection test based on helicase-dependent amplification and lateral-flow assay methods. A common pathogen of fish infections is the Flavobacterium genus bacteria, which can cause fish death in a few days after the initial infection. Even if these systems reduce the use of terrestrial resources, water recirculation in such systems can cause significant losses because of bacterial or viral infections.

That make intensive fish production compatible with environmental sustainability. Growing fish consumption rates encouraged marine culture farms to implement recirculating aquaculture systems
